Towards a more standardized bicuspid aortic valve repair: Impact of active aortic annulus remodeling on 4D flow MRI patterns and functional outcome

Additional caption: 
[A] Velocity-coded 4D flow MRI reveals an accelerated eccentric asymmetric flow jet (indicated by yellow and red streamlines) and a pronounced vortical flow pattern (arrows) in the ascending aorta before surgery.  The flow jet impacts and travels along the right aortic wall. [B] After surgery, velocity-coded 4D flow MRI shows reduced vortical flow with a more cohesive central flow pattern more parallel to the vessel wall of the ascending aorta. 
 

A Look Back: $$ 6th ForTra Workshop on Translational Research: “Financing and manufacturing – important things to consider to propel your project from lab to clinic”

The 6th Translational Research Workshop held by ForTra gGmbH für Forschungstransfer, a subsidiary of Else Kröner-Fresenius-Stiftung, took place from the 9th to the 10th of September, 2024 at Goethe University Frankfurt in the prestigious Casino hall on its Campus Westend. The workshop addressed medical doctors and natural scientists who concern themselves with the challenges posed by translational research. The focus was placed above all on aspects regarding financing and manufacturing, key factors in bringing a project as quickly as possible from the lab to the clinic.

Das EKFZ für Ernährungsmedizin erhält Lehrstuhl für Translationale Ernährungsmedizin

Prof. Alexander Bartelt ist Biochemiker und Molekularbiologe. Sein akademischer Werdegang umfasst bedeutende Positionen in führenden Institutionen, darunter die Harvard University (USA), wo er wesentliche Beiträge zur Adipositas- und Stoffwechselforschung geleistet hat. Seine Arbeit wurden in zahlreichen hochrangigen wissenschaftlichen Journalen publiziert und durch bedeutende internationale Auszeichnungen gewürdigt. Vor seinem bevorstehenden Wechsel an die TU München war er Professor für kardiovaskulären Stoffwechsel an der Ludwig-Maximilians-Universität München.

Checking back: What is Prof. Dr. Florian Tran, Else Kröner Memorial Fellow, doing these days?

After completing an early-studies program in Mathematics, Tran commenced his work toward a degree in Human Medicine at Kiel University (CAU) in Kiel and at University College London – as recipient of a scholarship awarded by the German Academic Scholarship Foundation. As of 2017 he subsequently worked as an intern in the Dept. of Internal Medicine I at the University Hospital Schleswig-Holstein, Kiel Campus.

Leave of absence from clinical responsibilities: € 250,000 for research to combat cancer, Parkinson’s, skin and neuro-degenerative diseases

Bad Homburg v. d. Höhe, August 29, 2024 – The foundation Else Kröner-Fresenius-Stiftung (EKFS) awards its Else Kröner Memorial Fellowships to six particularly talented young physicians. Each fellowship amounts to 250,000 euros, and with this grant for individuals EKFS supports medical doctors who are active in clinical and scientific fields at the start of their professional careers.

Disease Modification -Sustainable influence on atopic dermatitis with systemic therapies

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which is associated with a significant impairment of quality of life. In recent years, various biologics and Janus kinase inhibitors have been approved for the treatment of AD, which are directed in particular against this type 2 immune response. However, the extent to which long-term disease modification occurs during treatment has not yet been extensively investigated.

Microglial modulation of Parkinson Disease-associated midbrain pathology in chronic gut inflammation

Gut inflammation and its propagation into the brain can contribute to the development of Parkinson Disease. Previous findings imply that chronic gut inflammation is sufficient to cause inflammatory activation of resident immune cells, so-called microglia, and dopaminergic neuron loss in the midbrain, which is characteristic for Parkinson Disease. The aim of the project is to decipher molecular immune cell signatures in the midbrain in a mouse model of chronic gut inflammation and brain tissue of patients with inflammatory bowel disease by state-of-the-art techniques.

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