Gut inflammation and its propagation into the brain can contribute to the development of Parkinson Disease. Previous findings imply that chronic gut inflammation is sufficient to cause inflammatory activation of resident immune cells, so-called microglia, and dopaminergic neuron loss in the midbrain, which is characteristic for Parkinson Disease. The aim of the project is to decipher molecular immune cell signatures in the midbrain in a mouse model of chronic gut inflammation and brain tissue of patients with inflammatory bowel disease by state-of-the-art techniques. Microglia will be modulated as potential therapeutic targets to ameliorate Parkinson Disease-related alterations in chronic gut inflammation.