Project description:
The microbiome is a predictor of clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation. Microbiota-derived metabolites can modulate these outcomes. How bacteria, fungi and viruses contribute to the production of intestinal metabolites is still unclear. Multimodal analysis of stool samples of patients receiving allo-SCT (n = 78) uncovered a microbiome signature correlating with the production of immunomodulatory metabolites, which were associated with improved survival and reduced relapse. A high abundance of short-chain fatty acid-biosynthesis pathways was detected in bacteria and bacteriophages of low-risk patients. Our study provides a rationale for considering metabolite-producing consortia and metabolite formulations as microbiome-based therapies.
Publication:
Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Paul Heinrich, Jinlong Ru, Sakhila Ghimire, Oriana Miltiadous, Sarah Lindner, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sascha Göttert, Sebastian Jarosch, Katja Steiger, Christian Schulz, Michael Gigl, Julius C. Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Marcel R. M. van den Brink, Daniela Weber, Matthias Edinger, Daniel Wolff, Dirk H. Busch, Karin Kleigrewe, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler & Hendrik Poeck. Bacteria and bacteriophage consortia are associated with protective intestinal metabolites in patients receiving stem cell transplantation. Nature cancer, January 2024.
Paper: https://www.nature.com/articles/s43018-023-00669-x
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
