Project description:
Multiple sclerosis (MS) is an inflammatory disease of the brain and spinal cord that can lead to neurological deficits from young adulthood, despite immunomodulatory therapies. This study by the team at the Institute of Neuroimmunology and Multiple Sclerosis (INIMS) at the University Medical Center Hamburg-Eppendorf identified a new central mechanism of neurodegeneration in MS. They found that chronic inflammation leads to the formation of the protein STING in neurons, which triggers a signaling cascade causing cell death. Both pharmacological and genetic interventions protected against neurodegeneration in the MS mouse model. This study provides a basis for new neuroprotective therapies in MS and possibly other neurodegenerative diseases.
Publication:
Woo MS*, Mayer C*, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024 Jul. *contributed equally
Paper: https://linkinghub.elsevier.com/retrieve/pii/S0092867424005762
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
