Search result

Filter
1832 Results
The dual farnesoid X receptor and soluble epoxide hydrolase modulator (FXRA/sEHi) was designed by rational pharmacophore fusion and is currently evaluated for (synergistic) efficacy and improved safety in preclinical studies.
Projekt

Preclinical characterization of an innovative dual FXR/sEH modulator as experimental drug to treat non-alcoholic steatohepatitis

Institution: Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt
Applicant: Dr. phil. nat. Daniel Merk, Johann Wolfgang Goethe-Universität Frankfurt

The SPIONDEX iron oxide oxide nanoparticles are synthesized at SEON and extensively characterized and tested toxicologically, both in vitro and in vivo. They will be used as contrast agents in magnetic resonance imaging.
Projekt

Safe Contrast Agents for Magnetic Resonance Imaging (MRI)

Institution: Sektion für Experimentelle Onkologie und Nanomedizin (SEON), Else Kröner-Fresenius-Stiftungsprofessur für Nanomedizin, Hals-Nasen-Ohrenklinik, Kopf- und Halschirurgie, Universitätsklinikum Erlangen, Uni-Kl. Erlangen
Applicant: Prof. Dr. med. Christoph Alexiou

Schema zum möglichen therapeutischen Einsatz von MYB Inhibitoren
Projekt

Inhibition des Transkriptionsfaktors MYB mit niedermolekularen Substanzen

Institution: Institut für Biochemie, Universität Münster
Applicant: Prof. Dr. Karl-Heinz Klempnauer

Overview of inflammatory mechanisms in Duchenne muscular dystrophy and beneficial effects of immunoglobulin G.
Projekt

Effect of human immunoglobulin G on immune-mediated pathology of Duchenne muscular dystrophy

Institution: Department of Neurology, University Medical Center Göttingen, Göttingen, Germany
Applicant: Dr. med. Jana Zschüntzsch

Regulation of apoptosis by BCL2 proteins and BH3-mimetics
Projekt

Understanding and tackling resistance to BH3-mimetics in Diffuse Large B-cell Lymphoma

Institution: Goethe University Frankfurt
Applicant: Dr. Meike Vogler

Dr. Giannou (NP, MD, Msc, PhD) im mikrochirurgischen Labor
Projekt

Einfluss von IL-22 und IL-22BP auf die Lebermetastasierung

Institutions: I. Medizinische Klinik und Poliklinik Universitätsklinikum Hamburg-Eppendorf
Applicant: Anastasios Giannou

Expression of TREK1 in structures of the myovascular unit.
Projekt

TREK1 as critical regulator of the myovascular unit.

Institution: Department of Neurology with Institute for Translational Neurolgy
Applicant: Tobias Ruck

Cap on: Project leader Dr. Dr. Susanne Lütje at the cell culture bench
Projekt

Development and characterization of a triple-modality PSMA targeting agent for radionuclide and fluorescence imaging, image-guided surgery and photoimmunotherapy of prostate cancer

Institution: Department of Nuclear Medicine, University Hospital Bonn
Applicant: Dr. Dr. Susanne Lütje

Pathogenic antibodies may modulate signaling of neurons. We measure the altered currents to explain symptoms of the patients.
Projekt

Pathogenese paraneoplastischer neurologischer Erkrankungen

Institutions: Institute for Clinical Neuroimmunology, Biomedical Center and University Hospital. LMU Munich; Clinic of Neurology and Institute of Translational Neurology, University Hospital Münster
Applicants: Klaus Dornmair and Sven Meuth 

Intraoperative cardiovascular management
Projekt

Personalized intraoperative blood pressure management based on the patient-specific 24-hour blood pressure profile: impact on postoperative organ function

Institution: Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf
Applicant: Dr. med. Julia Nicklas