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By mimicking a viral infection in tumor cells a specific immune response against the tumor is triggered.
Projekt

Cell-specific targeting of therapeutic nucleic acids for tumor therapy

Institution: Abteilung für Klinische Pharmakologie, Klinikum der Universität München
Applicant : Dr. Lars König

Immune cell infiltration of renal cancer
Projekt

Impact of HIF to the immunological tumor microenvironment and multi-drug testing in clear cell renal cell carcinoma

Institution: Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University of Freiburg
Applicant: Rouven Höfflin, Ian Frew

Visualisation of the entorhino-hippocampal projection in vitro using viral tracing. Scale bar = 150 µm.
Projekt

Single-cell characterization of synaptic transmission at the entorhino-hippocampal projection

Institution: Department of Neuroanatomy, Institute of Anatomy and Cell Biology. University of Freiburg
Applicant: Maximilian Lenz

Clinician Scientist of the Else Kröner-Forschungskolleg „Targeted Therapies“ Frankfurt at work in the laboratory
Projekt

Targeted Therapies

Institution: University Cancer Center (UCT) Frankfurt
Applicants: Prof. Simone Fulda, Prof. Christian Brandts

Graphical overview of expected targets of Calca-derived peptides in the fracture callus.
Projekt

Investigation of Calca-encoded peptides to model divergent mechanisms governing bone regeneration

Institution: Department of Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf
Applicant: Johannes Keller

Histochemical AEC staining of Ki-67 (A), nestin (B), CD31(C) of murine medulloblastoma slices.
Projekt

In vivo investigations concerning the combinatorial treatment of medulloblastoma with 5-aza-2‘-deoxycytidine, abacavir, and irradiation

Institution: Department of Radiooncology, University of Leipzig
Applicant: Dr. Ina Patties

Left: Bladder cancer is molecularly diverse. By combination of different methods including high-througput analyses we investigate proteins involved. Right: Dr. F. Dressler, J. Schoenfeld and Biologist O. Revyakina (from left to right)
Projekt

Tumor-specific protein signature of urinary bladder carcinoma

Institution: Institute of Pathology, University Medical Center Schleswig-Holstein, Luebeck Site
Applicant: Dr. med. Franz F. Dreßler

FPLC-based protein purification
Projekt

Erforschung der molekularen Grundlage des MIA-Proteins bei der Metastasierung im malignen Melanom

Institutions: Ruhr-Universität Bochum und Universitätsklinikum Essen
Applicants: Prof. Dr. Raphael Stoll und PD Dr. Iris Helfrich

Project vision
Projekt

Immune diagnostics of an hereditary cancer predisposition syndrome: A functional test for Lynch syndrome?

Institutions: Abteilung für Angewandte Tumor Biologie, Institut für Pathologie, Universitätsklinikum Heidelberg
Applicants: Matthias Kloor, Aysel Ahadova, Magnus von Knebel Doeberitz

The dual farnesoid X receptor and soluble epoxide hydrolase modulator (FXRA/sEHi) was designed by rational pharmacophore fusion and is currently evaluated for (synergistic) efficacy and improved safety in preclinical studies.
Projekt

Preclinical characterization of an innovative dual FXR/sEH modulator as experimental drug to treat non-alcoholic steatohepatitis

Institution: Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt
Applicant: Dr. phil. nat. Daniel Merk, Johann Wolfgang Goethe-Universität Frankfurt