Targeted dietary interventions beyond caloric restriction as novel preconditioning strategies for acute kidney injury – a translational research approach

Project start
Institution: Department II of Internal Medicine, Center for molecular Medicine Cologne (CMMC) and CECAD Research Center, University Hospital of Cologne
Applicant: Dr. med. Felix Carlo Köhler
EKFS funding line: First Application
Image: Graphic

Acute kidney injury is a frequent and harmful disease. Currently, preventive and therapeutic strategies are lacking. Interestingly, specific diets have shown an amazing potential to prevent acute kidney injury in rodents. However, translation to the clinic is still lagging behind, since the optimal diet for humans and the molecular mechanisms mediating diet-induced stress-resistance are unknown. In the project at hand, we will compare the efficacy of five dietary regimens in two rodent models of acute kidney injury. This comparative approach facilitates an informed choice of the most appropriate diet and allows their molecular characterization. In parallel, these diets are examined in a “first-in-man” pilot-trial in the setting of living kidney donation to examine feasibility in humans.

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