Liver diseases affect 29 million people in Europe. Under stress from factors like aging, alcohol, and high-fat diets, liver cells can stop working properly, entering a state called senescence. This leads to fat build-up and inflammation, worsening a mild condition to a severe disease state called MASH. Our research indicates that the cellular senescence is common and worsens liver issues by attracting immune cells and causing fibrotic scarring. The scientists aim to: 1) uncover how these senescent cells contribute to fat build-up, 2) understand how processes in these cells accelerate liver problems, and 3) develop new treatments to prevent or slow disease progression by targeting these cells. Ultimately, the goal is to find effective strategies to combat liver disease and improve patient outcomes.

Further information here.