The Role of Autophagy in trophoblasts in the pathophysiology of preeclampsia

Project start
Institution: Geburtshilfe und Perinatale Medizin Goethe-Universitätsklinik Frankfurt
Applicant: Lukas Jennewein
EKFS funding line: First application
Image: Lukas Jennewein

Preeclampsia is a pregnancy complication leading to premature birth and organ failure with a high mortality worldwide. The exact underlying mechanisms leading to this disease are unknown. The responsible organ seems to be the placenta.
Autophagy is a cell digestion mechanism mediating cell resistance to stress. Impaired autophagy might lead to disturbed cell function and disrupted placenta development leading to preeclampsia. The aim of this study is to decipher the role of autophagy in the development of preeclampsia.

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