Transplant engineering of allogeneic keratinocytes - reduction of immunogenicity by potentiating regulatory unique short glycoproteins of human cytomegalovirus

Institution: Department of Plastic, Aesthetic, Hand and Reconstructive Surgery Hannover Medical School
Applicant: Dr. Frederik Schlottmann

Funding line:

First and Second Applications

Precision research in the laboratory: Cell culture experiments to modulate the immunogenicity of allogeneic keratinocytes through regulatory unique short glycoproteins of human cytomegalovirus

In the care of severely burned patients, there is often insufficient autologous skin available for skin transplantation. Therefore, allogeneic skin cells are to be modified so that they would become universally transplantable without causing a rejection reaction. For this purpose, components of the
cytomegalovirus are transferred and expressed in the genome of skin cells using various gene therapy methods. To generate a skin-like construct, the modified skin cells are grown on skin substitutes and implanted into fertilized chicken eggs to form their own blood vessels. The long-term goal remains the creation of a patient-specific skin substitute with high functionality and low rejection tendency.

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