Nonmuscle actin filaments in health and disease

Project start
Institution: Institute of Clinical Genetics University Hospital Carl Gustav Carus at the Technische Universität Dresden
Applicant: PD Dr. med. habil. Nataliya Di Donato
EKFS funding line: Else Kröner Exzellenzstipendium
Image: research group

DNA modifications in the actin genes ACTB and ACTG1 can lead to developmental disorders and organ malformations known as non-muscular actinopathies (NMA). In the granted project, the human geneticist Dr. Nataliya Di Donato aims at elucidating the mechanisms that lead to NMA and investigates the relationships between the various genetic disorders and the resulting disease patterns. Research into these very rare diseases helps to understand the function of one of the most vital proteins and at the same time opens up the possibility of developing a specific therapy for patients with rare actinopathies in the future.

Here you can find further information.