Immune System
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A multi-dimensional consensus atlas of skeletal muscle inflammation
Funding line:
Else Kröner Memorial Fellowships
For generating the atlas, PD Dr. Christopher Nelke performs the integration.
(© Christopher Nelke, BG Universitätsklinikum Bergmannsheil Bochum)
Idiopathic inflammatory myopathies are rare, complex muscle diseases that pose a significant burden for affected patients. The goal of this project is to create a transcriptomic atlas of these diseases, focusing on gene expression. We collaborate with several international research centers to generate a meaningful dataset. To achieve this, single-cell, single-nucleus, and spatial transcriptomic data will be integrated using biostatistical methods to create a high-resolution map of muscle tissue. The resulting atlas will be made publicly accessible and is intended to provide new insights into disease mechanisms, thereby laying the foundation for future therapies.