The β2-adrenergic receptor is the pharmacological target for clinically important bronchodilators and tocolytics. It is also the prototype model receptor. Although studies on the β2-adrenergic receptor have provided essential insights into the regulation of G protein-coupled receptors (GPCRs), they remain limited to in vitro cell systems. Our newly generated in vivo tag model offers the possibility to localize the receptor despite low expression in different tissues and to characterize the regulation in native tissues for the first time. This opens up potential possibilities to develop new β2-adrenergic receptor agonists with optimized therapeutic properties.

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