Chest Area
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First longitudinal data on the development and pathophysiology of diaphragmatic atrophy and dysfunction as a quantifiable key determinant of prolonged weaning in invasively ventilated patients in the intensive care unit.
Funding line:
Else Kröner Excellence Fellowships
Jens Spiesshoefer (MD and PhD) after a physiological measurement of lung muscle strength in his laboratory for translational pneumology.
(© PD Dr. Dr. med. Jens Spiesshoefer)
The present highly personnel (and technology) intensive research project is intended to use the gold standard for diaphragmatic strength determination for the first time by means of gold standard techniques established in only a few laboratories in the world based on our established laboratory infrastructure in Aachen, in order to determine the extent of the development of VIDD by repeated measurements throughout invasive mechanical ventilation for the first time and to make its weakness determinable as a biomarker after the project. This could improve the ventilation and weaning of millions of patients around the world.
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