Prediction of procedural result analysis using computational fluid dynamics of a multicenter, randomized, controlled study to assess Mitral vAlve reconsTrucTion for advancEd insufficiency of functional or iscHemic ORigiN (MATTERHORN Long Term)
The “MATTERHORN Long Term” project compares the long-term therapeutic success of transcatheter mitral valve edge-to-edge repair (M-TEER) with surgical treatment in patients with functional mitral regurgitation. The original MATTERHORN study showed that, after one year, M-TEER was not inferior to surgery. The current project will now examine whether differences in durability, cardiac function, and clinical outcomes emerge over a longer follow-up period.
In addition, a computational model based on flow simulations, known as computational fluid dynamics (CFD), will be validated. Using ultrasound images, this model is intended to predict how much mitral valve leakage remains after the procedure and whether the valve can still open sufficiently afterward. This is important because current procedural planning depends heavily on experience and subjective image interpretation.
The project will analyze 105 M-TEER patients from the MATTERHORN study. Imaging data will be evaluated centrally and compared with the CFD results. In the long term, this approach could provide an objective and reproducible tool for patient selection, procedural planning, and device choice.
