T cells are immune cells that protect against infections or cancer, but can also cause chronic inflammatory or autoimmune diseases. T cells recognize their target via the T cell receptor (TCR). The human body harbors billions of different TCRs. Therefore, assigning the correct TCR and its target is an enormous challenge. In the proposed project, we will combine innovative experimental methods with machine learning in a clinical cohort of yellow fever vaccinees to predict which target a TCR will recognize. In the future, this may help to identify therapeutically attractive TCRs and their targets, and thus improve vaccination and the prevention and therapy of any disease in which T cells play a role.

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