Analysis of a novel ADPKD disease modifier with a 3D bioprinting ‘kidney‐on‐chip’ platform and an in vivo model

Institution: Medical Center – University of Freiburg
Applicant: Dr. Roman Pichler

Funding line:

First and Second Applications

Medical Center – University of Freiburg, Department of Nephrology, lab of Dr. Roman Pichler; analysis of ADPKD disease modifiers.

Autosomal‐dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder in humans. Patients with ADPKD develop countless fluid‐filled cavities in their kidneys,
which lead to kidney failure and to the need for dialysis treatment. The project aims to develop new treatment options for this disease. Applying 3D cell culture techniques, a “kidney‐on‐chip” platform,
and an in vivo model, potential disease modifiers will be investigated, which play a crucial role in vitamin A metabolism and which are upregulated in ADPKD. By genetic targeting and drug‐ induced inhibition of specific enzymes we will try to slow down the disease course and to mitigate disease burden. Hopefully, this will lead to deeper insights into mechanisms of cyst development and growth
in ADPKD.

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