Abdominal Area, Kidneys & Pelvis
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Plasma activated liquids for the prevention of postoperative intra-abdominal adhesions (EndoPAL)

Institution: Department für Frauengesundheit, Medizinische Fakultät Tübingen
Applicant: Jun.-Prof. Dr. med. Martin Weiss
Funding line:
Translational Research
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Postoperative adhesions are pathologically occurring bridges of connective tissue between the peritoneum of the abdominal organs and the abdominal wall, which occur in 67-93% of all operations. Abdominal adhesions are responsible for severe and chronic pain syndromes, 15-20% of all cases of secondary infertility and for 50-70% of all mechanical ileus diseases. The annual costs due to abdominal adhesions are estimated between 1.18 and 1.33 billion US dollars solely for the US health system.
There is a considerable need for effective technologies to prevent postoperative adhesions, that can be routinely integrated into the surgical procedure.
Plasma activated liquids (PAL) are able to influence the proliferation and protein biosynthesis of connective tissue cells. PAL was shown to prevent an excessive formation proadhesive molecules.
The EndoPAL proposal aims to further develop and validate the PAL application using an ‘in vivo like’ environment. Therefore, a microfluidic peritoneum-on-chip model will be established, and the results will be confirmed in a suitable in-vivo animal model. This project will fasten and facilitate the translation of the innovative EndoPAL technology towards the clinical application.

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