In Germany, one in 12 infants is born prematurely, 10% of these infants are born before the 32nd week of gestation. Prematurity is the second-most common cause of child mortality during the first five years and one of the main reasons for lifelong disabilities. Both the occurrence of prematurity itself and the emergence of complications in premature infants are in many cases closely related to an inadequate response from the immune system. Dr.
Monoclonal antibodies (mAbs) have revolutionized the treatment of autoimmune diseases and cancer in the last two decades. Lately, an increasing number of mAbs are also being developed which are directly targeted against viruses and bacteria. These anti-infective mAbs have unique attributes that make them promising agents for novel treatment and prevention strategies against a broad spectrum of viruses and bacteria. However, physicians often lack experience with this new class of drugs, which hampers a broader clinical application.
Exposure-based psychotherapy is the first-line treatment for anxiety disorders with medium to high effect sizes on average. Nonetheless, 30-50% of treated patients experience poor symptom reduction or relapses. Consequently, our research strives to optimize exposure therapy. Specifically, using an innovative Bayesian adaptive study design, we aim to address the underlying mechanism of exposure treatments, test superiority of small-scale interventions (e.g., positive affect), and investigate clinical and neurobiological predictors of treatment response.
Pancreatic cancer is one of the most common causes of cancer-related deaths worldwide. In most patients, the tumor cannot be removed by surgery. Therefore, drug treatment options play a major role. The biology of each individual tumor is very different, so personalized therapies are becoming increasingly important. This project aims to establish a model in which the tumor is cultivated as an intact tissue section and used for individual treatment response testing.
Wissenschaftliches Arbeiten ist auch an Universitätseinrichtungen für Ärztinnen und Ärzte mit besonderen Herausforderungen und Problemen verbunden. Eines liegt darin, dass die Anforderungen der klinischen Arbeit zu Beginn der beruflichen Karriere keine zusammenhängende Forschungszeit für die Konzentration auf ein wissenschaftliches Forschungsvorhaben erlauben.
Parkinson's disease exhibits a variable course and various symptoms. Genetic changes have been identified in approximately 10% of cases, while the causes of the remaining cases remain unclear. In addition to genetic information, DNA methylation also influences information transmission within cells. This methylation is to be investigated in the De Novo Parkinson (DeNoPa) cohort over a period of ten years. The objective is to create and compare methylation profiles to identify differences and analyze changes in the course.
Bad Homburg v.d. Höhe, December 6, 2023 – Optimal compatibility of patient care and research: The foundation Else Kröner-Fresenius-Stiftung (EKFS) is awarding three Else Kröner Clinician Scientist Professorships. This is the fifth time in a row. Each of the professorships is endowed with 1.1 million euros over a maximum of ten years – provided that a positive interim evaluation occurs after five years. One application per faculty was admissible.
