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Bulimia nervosa is an eating disorder characterized by binge eating and purging behavior. Previous studies have shown the efficacy of inpatient treatment. With discharge and the associated increased confrontation with everyday stressors as well as the transition to outpatient therapy, there is often a renewed worsening of the symptoms. In order to counteract this development, a smartphone-based aftercare intervention could be a helpful addition to routine outpatient care.

Incorrect or poor blood vessel development in the womb lining (endometrium) can lead to a variety of complications including causing miscarriage. Further, it can also lead to growth restriction (IUGR) or pre-eclampsia (PE) during pregnancy. These (latter) conditions remain the leading cause of pre-term birth.

Type 1 Diabetes is a chronic autoimmune disease characterized by irreversible destruction of pancreatic insulin-producing cells. In Caucasians, Type 1 Diabetes onset is frequently diagnosed during childhood, predominantly between 5 and 15 years. In contrast, Type 1 Diabetes in sub-Saharan Africa is characterized by a significantly later age at onset with a delay of approximately 10 years.

Intact epithelial body surfaces represent physical barriers that protect the organism from invading pathogens and loss of nutrients. This barrier function contributes to intestinal immune homeostasis, which is fundamental for balanced immune responses and protection from overwhelming immune reactions. Irradiation can harm this intestinal barrier function which can lead to side effects after radiotherapy. We want to study fundamental mechanisms of intestinal tissue damage and epithelial regeneration after radiotherapy.

Glioblastoma multiforme WHO °IV (GBM) is the most frequent primary brain tumor in adults and has a devastating prognosis. Men develop GBM more frequently and have a shorter survival. The reasons for this are currently unknown and to date, there are no sex-specific therapeutic approaches. 30-40% of cells in a GBM consist of tumor associated microglia and macrophages.

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized clinically by motor dysfunction and currently affecting over 10 million patients world-wide. Some forms of PD are inherited and runs in families. The most common genetic cause of PD is a mutation Leucine rich repeat kinase 2 (LRRK2). The LRRK2 p.G2019S mutation accounts for up to 40% of familial PD in the Arab Berber population and 15-20% in Ashkenazi Jewish population. Even though patients have the exact same mutation, some patients can get PD at age 20 and some remain healthy at age 90.

Protein-protein interactions play an essential role in all molecular processes within the cell. Complexome profiling is one of the most recent ‘omics’ tools to get comprehensive insight into protein-protein interactions and protein complexes. Given that it generates a large number of samples, it requires very long measuring times and high costs. This project aims to combine peptide isotopic labelling with complexome profiling to enable pooling of samples before the analysis, reducing measuring times and costs several fold.

Improvements in systemic treatments for breast cancer have increased the rates of pathologic complete response (pCR) in patients receiving neoadjuvant systemic therapy (NAST), offering the opportunity to reduce surgery in patients who have a pCR. We include only patients with the highest likelihood of having a pCR after NAST (triple-negative or HER2-positive breast cancer). In the trial, axillary surgery will be eliminated completely for initially cN0 patients with radiologic complete remission and a breast pCR as determined in the lumpectomy specimen.