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Myocardial infarction (MI) is a major contributor to worldwide morbidity and mortality. MI occurs after atherosclerotic plaque rupture/erosion leading to atherothrombosis which in turn blocks supply of oxygenated blood to areas of the heart. Consequently, parts of the heart muscle become hypoxic and die off. This triggers a systemic inflammatory reaction which leads to an accumulation of inflammatory cells in the infarct area. These blood-derived immune cells exert different function during the course of MI.

Mild to moderate neurodevelopmental disorders (NDD) are poorly understood and late diagnosis and interventions result in a high burden for the society and health system.

Major depressive disorder (MDD) is a devastating illness affecting up to 10% of the population. Stress is a major risk factor for psychiatric diseases and acts on the basis of individual genetic risk. However, it is unclear how genetic factors predispose brain circuits to stress-induced changes underlying psychiatric disease.