Immune System
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Shiftless: a novel restrictor of retrotransposable elements and a gatekeeper of genome integrity
Funding line:
First and Second Applications
The protein SHFL is shown in red, the retrotransposon protein in green, and the cell nucleus is depicted in blue. Locations where both SHFL and the retrotransposon protein are present appear yellow.
(© Carl von Ossietzky Universität Oldenburg, Volker Kinast)
Retrotransposons are jumping genes in our genome that can cause a number of age-related and neurological diseases such as amyotrophic lateral sclerosis. The cellular protein shiftless appears to be an important factor in controlling retrotransposon activity. In this project, the team aim to uncover the molecular mechanism of shiftless and whether the factor can prevent the development of diseases. The results of the project may contribute to basic understanding of pathogenesis and to the development of new therapy and prevention strategies for neurological and age-related diseases.
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