Prediction, validation and prevention of post-chemotherapy cognitive impairment with human induced pluripotent stem cells (iPSC)

Project start
Institution: Klinik und für Neurologie mit Lehrstuhl für Experimentelle Neurologie, Charité Universitätsmedizin Berlin
Applicant: PD Dr. Petra Hühnchen
EKFS funding line: First and second applications
Image: Graphic

Cognitive impairment after chemotherapy is among the most frequent adverse events of cancer therapy, the development of which is still largely not understood. Induced pluripotent stem cells of breast cancer patients suffering from cognitive deficits after chemotherapy are differentiated into different brain cells and the influence of chemotherapy on these cells evaluated. Thereby, the underlying pathomechanisms of memory impairment after chemotherapy can be investigated in a human patient-specific disease model. The overall goal is an early identification of patients at risk and the examination of potential new preventive therapies.

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