The impact of HLA expression in urothelial carcinoma of the urinary bladder

Institution: Department of Urology, Technical Universiy Munich
Applicant: Thomas Horn. Julia Slotta-Huspenina

Funding line:

First and Second Applications

Composition of a Tissue Microarray for comparable examination of a high number of samples

Urothelial carcinoma is a frequent disease with a poor prognosis. Recently, immunotherapy with PD-1/PD-L1 inhibition has become an established treatment option.

Tumor cell expression of HLA (human leukocyte antigen) is a prerequisite for tumor antigen presentation and theoretically for the efficacy of cancer immunotherapy. Some tumors lose HLA expression over time.

Our project wants to describe the importance of HLA expression for the prognosis and response to immunotherapy in patients with urothelial carcinoma.

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