Immunotherapy stands for a great achievement for patients with various tumors. However, there are also patients who do not profit from this kind of therapy. Reliable markers to predict the response are still lacking. This would be desirable to prevent therapy induced side effects, allow an early change of the therapy regimen and reduce therapy related costs. Using analyses of peripheral blood immune cells bevor and after immunotherapy we want to find markers that allow a response prediction. Additionally, we want to regard the local immune reaction at the side of the tumor and answer the question whether it is reflected by peripheral blood immune cells.