Obese and diabetic patients frequently suffer from lung function impairment and chronic lung disease. This project aims at a better understanding of the structural and molecular alterations within pulmonary cells that are induced by high dietary intake of sugar or fat, and how these are affected by hypoxia and hyperoxia that can occur in the context of lung disease or therapeutic treatments. In this way we want to detect distinct pathomechanisms that can be used for novel therapeutic approaches. Moreover, we want to test the naturally occurring molecule spermidine that has been shown to exert beneficial effects on lifespan, cardiac function and lung structure for its therapeutic potential.

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