The most common cancer in men is prostate cancer. More than half of the tumors are localized and have a good prognosis. The decision for a treatment option is, however, extremely complex, as the available therapies differ considerably in terms of physical side effects and psychological burden. While the physical side effects of the therapies are already well documented, it is less known how men make their decision for a therapy and how they live with this decision in the long-term. We conducted a prospective, non-interventional study to investigate the association between decision making, disease-related anxiety, and coping strategies before, during, and after therapy. The findings will serve to improve medical counselling.