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Resistance exercise training has been shown to generate positive effects on pain and functionality in osteoarthritis of the knee. Unfortunately, only few people with osteoarthritic knee pain are motivated or even able to perform regular conventional resistance exercise. Whole-body electromyostimulation (WB-EMS) a time-efficient, joint-friendly and subjectively less strenuous intervention might be a feasible option to conventional resistance exercise.

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common hereditary disease worldwide. ADPKD belongs to disorders, which are commonly referred to as ciliopathies. Ciliopathies are due to defects in tiny structures – the primary cilia. Primary cilia are eyelash protrusion emanating from the cell surface that function as cellular antenna. Defects in this antenna function in the kidney cause cyst development. However, the molecular details how the antenna function is disturbed and why this leads to cyst development, is not well understood.

Nephrotic syndrome is a kidney disease characterized by protein loss in the urine, water retention and changes in blood lipids. Steroids are used to treat this disease without knowing exactly how they work in the kidney. Lysophosphatidic acids are a class of fat molecules that circulate in the blood, and also bind as signaling molecules to receptors in the kidney. We think that in nephrotic syndrome the composition of the lysophosphatidic acids in the blood is changed and that steroids have a positive effect on these changes.