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Sepsis is a life-threatening condition in which a dysregulated immune response can lead to organ failure. One frequent and particularly dangerous complication is sepsis-induced coagulopathy. In this condition, the coagulation system becomes imbalanced, and small blood clots can form. As a result, blood flow to vital organs may be further impaired. The mechanisms underlying this coagulation disorder are still incompletely understood.

Depression is one of the most prevalent and disabling disorders worldwide. Current antidepressants often take weeks to work and fail in a significant number of patients. The project aims to develop a novel, fast-acting, and well-tolerated antidepressant by targeting the GluN2D subunit of the NMDA receptor - a mechanism the scientists identified as key to ketamine’s antidepressant effects in preclinical studies.

In Germany, young people with mental health problems often wait up to six months for treatment. These delays can worsen symptoms, lead to chronic problems, or cause school difficulties. Quick help, like single-session interventions (SSI), can bridge this gap and prevent deterioration. This study tests whether two personalized SSIs, tailored to each individual’s needs, work better than standard SSIs. Personalized SSIs will focus on the symptom that is most linked to others in individual symptom networks, based on either a self-reported perceived causal or a data-driven network model.

The aging process is associated with an increased risk of chronic diseases and a decline in physical and cognitive functions. Physical activity, particularly endurance exercise training, can counteract these changes, but the underlying biological mechanisms are largely unclear. The "HEAL" project investigates whether endurance exercise training mediates anti-aging effects via the metabolism of the amino acid tryptophan in middle-aged adults.