Investigating autoimmune pathogenicity of single nucleotide polymorphism -linked truncated variants of TSH-receptor gene in Graves’ disease: an approach to applying genetics to personalized medicine

Graves‘ disease (GD) is an autoimmune condition affecting the thyroid gland. Thyroid eye disease (TED) is the associated inflammation of the eye, which leads to a reduction in quality of life. One of the confirmed genes of the disease is the TSHR gene. Small changes in the nucleotide sequence of TSHR gene have been found to play a role, known as SNP´s. More specific the variants ST4 and ST5 could act as main autoantigens.

Systemic PET and MR immunoimaging in heart failure with preserved ejection fraction

The prognosis of heart failure with preserved ejection fraction (HFpEF) is poor, and the prevalence of HFpEF is expected to continue rising, while diagnosis and assessing the disease status of HFpEF remains challenging. Therefore, there is an urgent clinical need to develop and validate new readouts to study the immune response in HFpEF as a potential prognostic marker for cardiac outcomes.

Else Kröner Promotionskollegs 2025 (only available in German)

Die Else Kröner-Fresenius-Stiftung möchte die Medizinischen Fakultäten in Deutschland unterstützen, besonders interessierte und begabte Medizinstudierende für wissenschaftliche Forschungstätigkeit zu begeistern und zu gewinnen. Die Studierenden sollen in Promotionskollegs die Möglichkeit erhalten, eine anspruchsvolle Promotion durchzuführen und wissenschaftliche Karrierewege kennen zu lernen.

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