The bone marrow microenvironment (BMM) represents the ‘home’ for normal haematopoietic stem cells (HSC) or blood stem cells, which give rise to all the various blood cells. The respective interplay between the BMM and HSC is slowly being elucidated, but evidence for a definitive role of the proteins of the blood clotting system for the control of haematopoietic homeostasis is scarce and non-existent in the case of leukaemia, a malignant disease of HSC. 

As we believe that the coagulation system plays a previously underdefined role in normal and malignant haematopoiesis via influencing of the BMM, we will test this n the current study with the help of various experimental settings. Our results will have an important impact on our understanding of haematopoiesis and will yield novel strategies which will augment normal haematopoiesis on the one hand and impair leukaemia progression on the other. 

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