The role of central insulin resistance in the development of depressive symptoms

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Institution: Department of Psychiatry, Psychosomatic Medicine, Psychotherapy, University Hospital Frankfurt, Goethe University
Applicant: Sharmili Edwin Thanarajah
EKFS funding line: Else Kröner Memorial Fellowship
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Diabetes and depression often occur together and are the leading causes of disability worldwide. However, the mechanisms underlying this high comorbidity rate are unclear. In this study, we use brain imaging, behavioral experiments and blood tests to investigate whether reduced sensitivity to the metabolic hormone insulin and chronic inflammatory processes are related to brain functional changes and depressive symptoms in both disorders.

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