Neurocomputational mechanisms of fatigue in Long-COVID and their links to immune activation

Project start
Institution: Lübeck University, Department of Psychiatry and Psychotherapy, Social Neuroscience Lab
Applicant: Dr. rer. nat. David Sören Stolz
EKFS funding line: First and Second Applications

One of the most common symptoms of "Long-COVID" is fatigue, i.e. persistent exhaustion on a mental or physical level. The team explores the yet unclear psychological and neurobiological processes that might contribute to the subjective experience of fatigue. To do this, they use a computer task in which people learn (mental level) whether their bodily efforts (physical level) are rewarded and how these processes interact. Using mathematical models and functional MRI, they describe behavior and brain activity during the task. In addition, the team will collect blood samples to test how these processes relate to immune activation. With this research, the scientists hope to expand knowledge about fatigue and thereby also contribute to the development of therapies.

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