Adrenocortical tumors and hypercortisolism represent significant endocrine disorders with complex pathophysiology. The research focuses on the pivotal role of mitochondria in adrenocortical function, particularly in steroidogenesis and cell proliferation. The scientists will investigate the effects of established treatments on mitochondrial function in vitro and in vivo, using advanced cell culture techniques and animal models. Additionally, they will explore novel mitochondria-targeted therapies, potentially uncovering synergistic effects with current treatments. By integrating molecular, cellular, and physiological analyses, they aim to develop a nuanced understanding of mitochondrial dysfunction in adrenocortical diseases. This research could pave the way for innovative, targeted therapies with improved efficacy and reduced side effects, ultimately enhancing patient outcomes in adrenocortical disorders.

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