Patients with chronic kidney disease have a markedly increased risk of heart failure, cardiac arrhythmias and sudden cardiac death. This close interaction between the heart and the kidneys is referred to as cardiorenal syndrome, characterized by dysfunction of one organ inducing or aggravating structural and functional damage of the other. The aim of this project is to investigate how impaired renal function drives cellular remodeling of the human myocardium. Using primary human cardiac tissue and human iPSC-Cardiomyocytes, disease-relevant mechanisms will be studied. The results are expected to provide novel mechanistic insights and to support the development of targeted therapies for patients with cardiorenal syndrome.