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Non-invasive precision diagnostics of primary aldosteronism (B2-MAP)

Institution: University Hospital Wuerzburg, Division of Endocrinology and Diabetes and Department of Nuclear Medicine
Applicant: Stefanie Hahner, Andreas Schirbel
Funding line:
Translational Research
Non-invasive precision diagnostics of primary aldosteronism (B2-MAP)
From invasive adrenal venous sampling to non-invasive molecular imaging: CYP11B2-targeted PET for localization of aldosterone overproduction in primary hyperaldosteronism.
(© Stefanie Hahner)

Primary aldosteronism is the most common curable cause of hypertension. Current subtyping relies on invasive adrenal venous sampling, which is technically demanding and available only in specialized centers. This project aims to develop a novel, highly specific PET tracer targeting aldosterone synthase, a key enzyme in the disease’s pathophysiology, to enable non-invasive localization of aldosterone overproduction. The overall goal is to simplify the diagnostic pathway for primary aldosteronism and advance precision medicine for affected patients.

 

Das „Bench-to-Bedside“-Team aus Endokrinologie und Nuklearmedizin des UKW.
The “Bench-to-Bedside” team from the Departments of Endocrinology and Nuclear Medicine at UKW.
(© Kirstin Linkamp / UKW)