The human immune system is equipped with a variety of different blood cells to fight a multitude of pathogens each day. Mutations in the genome can cause phagocytes like macrophages to become non-functional and these cells then fail to clear pathogens like mycobacteria. This is the case for the disease MSMD, in which patients suffer from severe and sometimes lethal mycobacterial infections. The funded project tries to develop novel therapy options for these patients. We investigate whether genetic correction of hematopoietic stem cells and the subsequent transplantation of these cells can save a relevant mouse model from otherwise lethal mycobacterial infections.