Cancer
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Immune escape mechanisms in head and neck squamous cell carcinoma: The role of HGF/Met signalling pathway
Funding line:
First and Second Applications
Our project is focused on a particular signaling pathway (HGF/Met signaling) and its influence on immunologic and metabolic changes in malignant tumors of the head and neck (oral cavity, throat, etc.). Recently, we showed that activation of a receptor (Met) results in enhanced glucose metabolism and expression of immunosuppressive proteins. Next, we intend to analyze how and to what extent immune cells are compromised by those HGF/Met-mediated changes. To this end, we use immune cells from human blood samples and determine their behavior in the presence of HGF-conditioned tumor cells.
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