In stroke, the blockage of blood vessels leads to the death of nerve cells. The longer the blockage, the more severe the consequences. The vessels of many patients can be reopened by using blood thinners (lysis) and catheter procedures. However, reopening does not guarantee that patients will benefit. Parallel inflammatory processes lead to ongoing stroke growth. These processes have not been therapeutically addressed so far. A protein complex called the inflammasome is a major regulator in these inflammatory processes. Inflammasome inhibitors in mouse models lead to smaller lesions and better neurological outcomes. The scientists aim to use these results to better understand the inflammatory processes and develop new therapeutic options. 

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