The number of people with obesity is continuously rising worldwide with major consequences for personal and public health but new weight loss drugs have revolutionised the treatment over the last years.
Obesity leads to a severe course of infections which was clearly demonstrated during the COVID-19 pandemic. The immune system protects from infections, but first studies suggest a immune-dampening effect of obesity. The aim of this study is to determine the impact of obesity and weight loss therapies on the immune response against clinically relevant infections with the goal to reveal underlying mechanisms. This will allow the development of novel immune-boosting therapies for obese people.