CNS lymphomas are aggressive brain tumors that are often difficult to diagnose and treat. To this day, little is understood of the biological mechanisms by which lymphoma cells infiltrate and spread within the brain. PD Dr. Florian Scherer and his team are developing highly sensitive liquid biopsy tests that are able to detect even the minutest trace of tumor DNA in blood and cerebrospinal fluid. This approach may enable faster and more reliable diagnoses in challenging clinical situations. The researchers are also using novel molecular technologies to better understand the development and spread of these lymphomas in the brain – paving the way for more precise and personalized treatment in the future.