Myocardial infarction and stroke are the main causes of morbidity and mortality worldwide, primarily caused by atherosclerosis, a chronic inflammatory disease of the arterial vessel wall. Macrophages (phagocytic cells) take over a key role in the development of atherosclerosis. Macrophages are recruited by inflammatory mediators of the immune system. However, as demonstrated in this publication, these mediators might have protective effects on macrophage programming depending on their respective source and origin. As now shown, distinct inflammatory mediators, when released from smooth muscle cells, can maintain a functionally protective phenotype of macrophages and reduce chronic inflammation in atherosclerosis. New anti-inflammatory approaches should therefore take into account protective effects of otherwise pro-inflammatory mediators within distinct compartments.
Kami Pekayvaz, Christoph Gold, Parandis Hoseinpour, ..., Christian Schulz, Steffen Massberg, Konstantin Stark, Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity Volume 56, Issue 10, 10 October 2023.
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