Project description:
When our body is injured or infected, it produces signals prompting immune cells to traffic from bloodstream via the vessel wall towards the affected area. However, the chronic activation of this process, known as “chronic inflammation”, can lead to tissue and organ damage. Chronic inflammation is a hallmark of ischemic heart disease, the leading cause of death. A study led by Dr. Aikaterini Gatsiou (Newcastle) and Prof. Konstantinos Stellos (Mannheim/Heidelberg and Newcastle) revealed that nucleotide chemical changes, introduced to the RNA by the RNA enzyme ADAR2, promote vessel wall responsiveness to circulating interleukin-6, and tissue inflammation in ischemic heart disease. This groundbreaking discovery offers novel insights in the RNA-based regulation of inflammation and paves the way for the development of RNA therapeutics in chronic inflammatory diseases.
Publication:
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli,..., Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos. The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation, Immunity. April 25, 2023
Paper: https://www.cell.com/immunity/fulltext/S1074-7613(23)00141-3
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
