Project description:
Myelodysplastic neoplasm (MDS) is characterized by malignant transformation of hematopoietic cells and can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Determining whether this is recipient derived or donor derived is essential for further treatment, as the correct donor selection avoids life-threatening side effects in the event of a repeated allo-HSCT. However, conventional methods fail to adequately address this question. Here, the authors solve the origin of MDS in a patient affected by this scenario. Using a customized single-cell-based strategy that identifies the MDS-associated U2AF1S34Y mutation, they reveal a recipient-derived MDS, thus providing the opportunity for an effective treatment. The study emphasizes the need to further develop and implement high-resolution approaches at single-cell resolution to advance personalized medicine.
Publication:
Ihlow J, Penter L, Vuong LG, Bischoff P, Obermayer B, Trinks A, Blau O, Behnke A, Conrad T, Morkel M, Wu CJ, Westermann J, Bullinger L, von Brünneck AC, Blüthgen N, Horst D, Praktiknjo SD. Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling. Med. 2025 Apr 11.
Paper: https://www.sciencedirect.com/science/article/pii/S2666634024004422?via%3Dihub
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
