Project description:
The CAR-T cell therapy is an innovative treatment method in which the body’s own immune cells, called T cells, are genetically modified in such a way that they can specifically recognize and destroy cancer cells. This modern therapeutic approach has revolutionized the treatment of patients with malignant lymphomas in recent years.
In very rare cases, however, secondary cancers, known as T-cell lymphomas, have been observed after CAR-T cell therapy. In close collaboration, researchers from Düsseldorf, Kiel, Heidelberg, and Berlin have been able to demonstrate that mutations in hematpoeitic stem cells existed before the T-cell therapy and played a major role in the development of the T-cell lymphoma. This phenomenon is referred to as clonal hematopoiesis. No evidence was found that the mechanism of CAR-T cell therapy itself caused lymphoma development, which may help reduce the growing uncertainty surrounding CAR-T cell therapy in recent times.
Publication:
Guido Kobbe, M.D., Monika Brüggemann, M.D., Ben-Niklas Baermann, M.D., Laura Wiegand, Heiko Trautmann, Ph.D., Schayan Yousefian, M.Sc. https://orcid.org/0000-0003-0902-0369, Silvana Libertini, Ph.D., +30, Frederik Damm, M.D. and Sascha Dietrich, M.D., Published October 2, 2024, N Engl J Med 2024.
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (a.asschenfeldt@ekfs.de).
More Paper of the Month can be found here.
