Use of different CPAP-levels in the delivery room and treatment of respiratory distress syndrome in very preterm infants – a randomized multicenter trial

Institutions: Department of General Pediatrics & Neonatology, Center for Pediatrics and Youth Medicine, Justus Liebig University of Giessen
Applicant: Dr. Markus Waitz
Funding line:
First and Second Applications
Teaching session for the application of CPAP in the delivery room

The development of bronchopulmonary dysplasia (BPD) in preterm infants is frequently associated with sustained impaired lung function, somatic growth and neurodevelopment. Mechanical ventilation is known to cause BPD. The use of nasal CPAP reduced the need and duration of mechanical ventilation. However, more than 50% of very preterm infants still require mechanical ventilation. The optimum level of distending pressure during nasal CPAP to further reduce the rate of treatment failure is unknown. This clinical trial aims to answer this question and the results will hopefully contribute to improved long term outcomes in these infants. 

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