The Puringe project aims to develop an innovative syringe-based system for precise and contamination-free injections, with an initial focus on intravitreal operative medication administration (IVOM). The core innovation is a flexible, impermeable membrane that physically separates the drug from the syringe at all times, thereby reliably preventing contamination by silicone oil or abrasion particles. At the same time, the Puringe functions as an integrated dosing aid, structurally eliminating overfilling and reducing the risk of overdosing and drug waste. The device is compatible with existing clinical workflows, connects to standard syringes and needles via a Luer-lock interface, and is designed for scalable mass production. Owing to the use of cyclic olefin copolymer (COC), the Puringe is well suited for sensitive therapeutics and prefilled applications, including storage at very low temperatures. Beyond IVOM, the Puringe is conceived as a platform technology with potential applications in mRNA-based medicines, gene and cell therapies. The overall goal of the project is to establish a robust regulatory pathway enabling rapid translation into clinical practice and market adoption for the benefit of patients and healthcare systems.