Patient-derived muscle stem cells for the treatment of muscle wasting and muscular defects
Project partner: Prof. Dr. Anne-Karoline Ebert, Leiterin, Pädiatrische Urologie, Universitätsklinikum Ulm
Skeletal-muscle stem cells repair muscle. We want to utilize this potential for the therapy of muscle wasting and muscle defects. Therefore, we developed muscle stem cells as an advanced therapeutic medicinal product (ATMP) to be transplanted in an autologous manner (PHSats).
We isolate, multiply, and store satellite cells in a process that was developed by us. The regenerative potential of PHSats was demonstrated in preclinical experiments, and safety issues were addressed. We are currently preparing the first-in-man clinical trial for repairing a defective urethral sphincter in a developmental disorder.
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