Ependymomas are malignant tumours of the brain and spinal cord. As they are very resistant to standard chemotherapy, their treatment can be very challenging. The project “MOMENT-MYCN” focuses on an aggressive, incurable subtype that primarily affects adolescents and young adults. This type of tumour, which was only discovered in 2019, is characterised by too many copies of a cancer gene called “MYCN”. The study investigates the influence of MYCN on cancer growth, biological processes in the individual cells and whether its blockade could inhibit the malignant cells from growing. In addition, clinical patient data will be analysed in order to develop a systematic concept for the treatment and diagnosis of this new and so far, enigmatic type of cancer.