Immunotherapies can help many. However, a significant number of patients will not benefit from these. A major reason for treatment failure is the suppressive tumor environment. Oncologists are more and more making use of local treatments for metastasis (surgery, radiotherapy, radiology) which appear to have an important immunological impact. Along these lines, such local interventions are predestined for combinations with immunotherapies. This is the focus of IOLIN which aims at generating evidence for the synergy of such combined modalities to the benefit of cancer patients.

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